Hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality worldwide, affecting more than 1.3 billion individuals. Despite the availability of multiple antihypertensive drug classes, nearly half of treated patients fail to achieve optimal blood pressure control, with resistant hypertension representing a major unmet clinical challenge. Excessive aldosterone production is increasingly recognized as an important driver of resistant hypertension, cardiovascular remodeling, chronic kidney disease, and heart failure. Conventional mineralocorticoid receptor antagonists effectively block aldosterone signaling but are frequently limited by hyperkalemia, endocrine adverse effects, and poor tolerability. Baxdrostat, a highly selective aldosterone synthase inhibitor (ASI), represents the first-in-class therapeutic strategy that directly inhibits aldosterone biosynthesis while preserving cortisol synthesis through selective inhibition of CYP11B2.

Vibrio harveyi poses a significant threat to shrimp aquaculture. In this study, we isolated seventy-six bacteriophages infecting luminescent V. harveyi from 194 water samples sourced from shrimp hatcheries along the South East coast and Andaman island of India. Utilizing Degenerate Primed Randomly Amplified Polymorphic DNA (DP-RAPD) fingerprinting, we investigated the genetic relatedness among these bacteriophages. The analysis, based on Dice coefficient and subsequent construction of a dendrogram using the unweighted pair group method with arithmetic averages (UPGMA), unveiled 12 distinct clusters. Transmission electron microscopy observations were conducted on one randomly chosen phage from each major cluster, revealing that eleven exhibited an icosahedral head (46-115 nm) with a long non-contractile tail (132-329 nm), classifying them under the Siphoviridae family. Meanwhile, two phages displayed a short tail (15-27 nm), placing them in the Podoviridae family. Phylogenetic analysis of the phages using DP-RAPD fingerprinting demonstrated partial correlation with the host's phenotypic characteristics, particularly in sucrose fermentation and source of isolation. However, phages infecting V. harveyi, despite belonging to different families, did not cluster together in the DP-PCR cluster analysis. This study underscores the genetic diversity among phages infecting the same host, particularly in light of phenotypic variations, as revealed by DP-RAPD.